EVEROLIMUS

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C53H83NO14
Molecular Weight	958.2244
Optical Activity	UNSPECIFIED
Defined Stereocenters	15 / 15
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of EVEROLIMUS

Structure Search

SMILES

[H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H](CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C2)OC)[C@H](C)C[C@@H]4CC[C@@H](OCCO)[C@@H](C4)OC

InChI

InChIKey=HKVAMNSJSFKALM-GKUWKFKPSA-N

InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C53H83NO14
Molecular Weight	958.2244
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	15 / 15
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:11:58 UTC 2023` Edited by `admin` on `Sat Dec 16 17:11:58 UTC 2023`
Record UNII	9HW64Q8G6G
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EVEROLIMUS

Official Name

English

EVEROLIMUS [MART.]

Common Name

English

RAD-666

Code

English

SDZ RAD

Common Name

English

EVEROLIMUS [ORANGE BOOK]

Common Name

English

ZORTRESS

Brand Name

English

RAD001

Code

English

EVEROLIMUS [USP-RS]

Common Name

English

SDZ-RAD

Code

English

everolimus [INN]

Common Name

English

CERTICAN

Brand Name

English

AFINITOR

Brand Name

English

EVEROLIMUS [EP MONOGRAPH]

Common Name

English

EVEROLIMUS [USAN]

Common Name

English

EVEROLIMUS [MI]

Common Name

English

Everolimus [WHO-DD]

Common Name

English

VOTUBIA

Brand Name

English

RAD-001

Code

English

EVEROLIMUS [JAN]

Common Name

English

EVEROLIMUS [EMA EPAR]

Common Name

English

RAD 666

Code

English

40-O-(2-HYDROXYETHYL)-RAPAMYCIN

Common Name

English

EVEROLIMUS [VANDF]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

374012

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

NDF-RT

N0000175625

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

WHO-ATC

L04AA18

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

EU-Orphan Drug

EU/3/07/488

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

FDA ORPHAN DRUG

315410

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

WHO-VATC

QL04AA18

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

EMA ASSESSMENT REPORTS

VOTUBIA (AUTHORIZED: TUBEROUS SCLEROSIS)

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

NDF-RT

N0000175605

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

NCI_THESAURUS

C574

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

NCI_THESAURUS

C2201

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

EMA ASSESSMENT REPORTS

AFINITOR (AUTHORIZED: CARCINOMA, RENAL CELL)

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

WHO-ATC

L01XE10

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

FDA ORPHAN DRUG

283609

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

FDA ORPHAN DRUG

254107

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

EMA ASSESSMENT REPORTS

AFINITOR (AUTHORIZED: PANCREATIC NEOPLASMS)

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

FDA ORPHAN DRUG

489715

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

NDF-RT

N0000175076

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

FDA ORPHAN DRUG

340111

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

NCI_THESAURUS

C1742

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

FDA ORPHAN DRUG

431214

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

WHO-VATC

QL01XE10

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

LIVERTOX

NBK548857

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

Code System Code Type Description

FDA UNII

9HW64Q8G6G

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

HSDB

8255

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

MERCK INDEX

m5220

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

Merck Index

ChEMBL

CHEMBL1908360

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

NDF-RT

N0000182141

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

Cytochrome P450 3A4 Inhibitors [MoA]

USAN

MM-04

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

DAILYMED

9HW64Q8G6G

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

DRUG BANK

DB01590

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

INN

7863

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

CAS

159351-69-6

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

IUPHAR

5889

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

WIKIPEDIA

EVEROLIMUS

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

MESH

C107135

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

EPA CompTox

DTXSID0040599

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

PUBCHEM

6442177

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

DRUG CENTRAL

1118

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

NDF-RT

N0000182137

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

Cytochrome P450 2D6 Inhibitors [MoA]

SMS_ID

100000092327

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

RS_ITEM_NUM

1268976

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

EVMPD

SUB02065MIG

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

NDF-RT

N0000185503

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

P-Glycoprotein Inhibitors [MoA]

RXCUI

141704

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

RxNorm

CHEBI

68478

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

NCI_THESAURUS

C48387

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

LACTMED

Everolimus

Created by admin on Sat Dec 16 17:11:59 UTC 2023 , Edited by admin on Sat Dec 16 17:11:59 UTC 2023

PRIMARY

Related Record Type Details


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					9HW64Q8G6G

EXCRETED UNCHANGED

Comments:

No parent drug was detectable in urine and feces, indicating metabolism was the main clearance mechanism of everolimus

Qualification:

FECAL; URINE

Amount:


					1788PW098Q

SERINE/THREONINE-PROTEIN KINASE MTOR

TARGET -> INHIBITOR

Interaction Type:

ALLOSTERIC INHIBITOR

Related Record Type Details


					ECI6WI7P2Q

7-O-DEMETHYL-42-O-(2-HYDROXYETHYL)RAPAMYCIN

METABOLITE -> PARENT

Amount:


					QKH7MLE47U

EVEROLIMUS ACID

METABOLITE -> PARENT

Qualification:

PLASMA

Amount:

Related Record Type Details


					W36ZG6FT64

SIROLIMUS

IMPURITY -> PARENT

Amount:


					SA2YXL34JA

42-O-FORMYL RAPAMYCIN

IMPURITY -> PARENT

Amount:


					QAQ4Q483BA

Everolimus-19-ene open ring

IMPURITY -> PARENT

Amount:

Related Record Type Details


					9HW64Q8G6G

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC				SINGLE DOSE ORAL ADMINISTRATION

Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION