DEPATUXIZUMAB MAFODOTIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 08:43:52 GMT 2025` Edited by `admin` on `Wed Apr 02 08:43:52 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	CHIMERIC/HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	F3R7A4P04N
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

depatuxizumab mafodotin [INN]

Preferred Name

English

DEPATUXIZUMAB MAFODOTIN

Official Name

English

IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS EGFR (EPIDERMAL GROWTH FACTOR RECEPTOR, RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1, ERBB1, HER1, HER-1, ERBB)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY CONJUGATED TO AURISTATIN F

Systematic Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR) (HUMAN-MUS MUSCULUS MONOCLONAL ABT-806 HEAVY CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL ABT-806 LIGHT CHAIN, DIMER, TETRAKIS(THIOETHER) WITH N-(6-(3-MERCAPTO-2,5-DIOXO-1-PYRROLIDI

Systematic Name

English

DEPATUXIZUMAB MAFODOTIN [JAN]

Common Name

English

Depatuxizumab mafodotin [WHO-DD]

Common Name

English

ABT-414

Code

English

DEPATUXIZUMAB MAFODOTIN [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C129825

Created by admin on Wed Apr 02 08:43:52 GMT 2025 , Edited by admin on Wed Apr 02 08:43:52 GMT 2025

FDA ORPHAN DRUG

433214

Created by admin on Wed Apr 02 08:43:52 GMT 2025 , Edited by admin on Wed Apr 02 08:43:52 GMT 2025

NCI_THESAURUS

C2167

Created by admin on Wed Apr 02 08:43:52 GMT 2025 , Edited by admin on Wed Apr 02 08:43:52 GMT 2025

Code System Code Type Description

WIKIPEDIA

DEPATUXIZUMAB MAFODOTIN

Created by admin on Wed Apr 02 08:43:52 GMT 2025 , Edited by admin on Wed Apr 02 08:43:52 GMT 2025

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SMS_ID

100000166799

Created by admin on Wed Apr 02 08:43:52 GMT 2025 , Edited by admin on Wed Apr 02 08:43:52 GMT 2025

PRIMARY

NCI_THESAURUS

C105612

Created by admin on Wed Apr 02 08:43:52 GMT 2025 , Edited by admin on Wed Apr 02 08:43:52 GMT 2025

PRIMARY

ChEMBL

CHEMBL3707277

Created by admin on Wed Apr 02 08:43:52 GMT 2025 , Edited by admin on Wed Apr 02 08:43:52 GMT 2025

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CAS

1585973-65-4

Created by admin on Wed Apr 02 08:43:52 GMT 2025 , Edited by admin on Wed Apr 02 08:43:52 GMT 2025

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USAN

CD-14

Created by admin on Wed Apr 02 08:43:52 GMT 2025 , Edited by admin on Wed Apr 02 08:43:52 GMT 2025

PRIMARY

FDA UNII

F3R7A4P04N

Created by admin on Wed Apr 02 08:43:52 GMT 2025 , Edited by admin on Wed Apr 02 08:43:52 GMT 2025

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DRUG BANK

DB11731

Created by admin on Wed Apr 02 08:43:52 GMT 2025 , Edited by admin on Wed Apr 02 08:43:52 GMT 2025

PRIMARY

INN

10263

Created by admin on Wed Apr 02 08:43:52 GMT 2025 , Edited by admin on Wed Apr 02 08:43:52 GMT 2025

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EVMPD

SUB181033

Created by admin on Wed Apr 02 08:43:52 GMT 2025 , Edited by admin on Wed Apr 02 08:43:52 GMT 2025

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From	To
1_22	1_96
1_143	1_199
1_219	3_214
1_225	2_225
1_228	2_228
1_260	1_320
1_366	1_424
2_22	2_96
2_143	2_199
2_219	4_214
2_260	2_320
2_366	2_424
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					O19V2N6W9T

MAFODOTIN

CONJUGATE COMPONENT->CONJUGATE


					RO03J093CP

EPIDERMAL GROWTH FACTOR RECEPTOR

TARGET->LIGAND


					W984C353CG

CONJUGATE COMPONENT->CONJUGATE


					RO03J093CP

EPIDERMAL GROWTH FACTOR RECEPTOR

TARGET->CONJUGATED TOXIN

Amount:

Related Record Type Details


					F3R7A4P04N

DEPATUXIZUMAB MAFODOTIN

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION			1_1; 2_1		PIDOLIC ACID	SZB83O1W42
AMINO ACID SUBSTITUTION	[1_219] [1_225] [1_228] [2_219] [2_225] [2_228] [3_214] [4_214]		C	Amount:	CYSTEINYL-MAFODOTIN	B4S8ET206U

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:CALCULATED	CHEMICAL
Molecular Formula	CHEMICAL