DEPATUXIZUMAB

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National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 21:27:32 GMT 2025` Edited by `admin` on `Mon Mar 31 21:27:32 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	CHIMERIC/HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	W984C353CG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DEPATUXIZUMAB

Official Name

English

depatuxizumab [INN]

Preferred Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR) (HUMAN-MUS MUSCULUS MONOCLONAL ABT-806 HEAVY CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL ABT-806 LIGHT CHAIN, DIMER

Common Name

English

Depatuxizumab [WHO-DD]

Common Name

English

ABT-806

Code

English

ANTI-EGFR MAB ABT-806

Common Name

English

IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS EGFR (EPIDERMAL GROWTH FACTOR RECEPTOR, RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1, ERBB1, HER1, HER-1, ERBB)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY GAMMA1 HEAVY CHAIN HUMANIZED (1-446) (HUMANIZED VH (HOMO S

Systematic Name

English

ANTI-EGFR MOAB ABT-806

Common Name

English

ANTI-EGFR MONOCLONAL ANTIBODY ABT-806

Common Name

English

DEPATUXIZUMAB [USAN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

361811

Created by admin on Mon Mar 31 21:27:32 GMT 2025 , Edited by admin on Mon Mar 31 21:27:32 GMT 2025

NCI_THESAURUS

C20401

Created by admin on Mon Mar 31 21:27:32 GMT 2025 , Edited by admin on Mon Mar 31 21:27:32 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C95206

Created by admin on Mon Mar 31 21:27:32 GMT 2025 , Edited by admin on Mon Mar 31 21:27:32 GMT 2025

PRIMARY

SMS_ID

100000174639

Created by admin on Mon Mar 31 21:27:32 GMT 2025 , Edited by admin on Mon Mar 31 21:27:32 GMT 2025

PRIMARY

USAN

CD-13

Created by admin on Mon Mar 31 21:27:32 GMT 2025 , Edited by admin on Mon Mar 31 21:27:32 GMT 2025

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DRUG BANK

DB12826

Created by admin on Mon Mar 31 21:27:32 GMT 2025 , Edited by admin on Mon Mar 31 21:27:32 GMT 2025

PRIMARY

ChEMBL

CHEMBL3707294

Created by admin on Mon Mar 31 21:27:32 GMT 2025 , Edited by admin on Mon Mar 31 21:27:32 GMT 2025

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CAS

1471999-69-5

Created by admin on Mon Mar 31 21:27:32 GMT 2025 , Edited by admin on Mon Mar 31 21:27:32 GMT 2025

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FDA UNII

W984C353CG

Created by admin on Mon Mar 31 21:27:32 GMT 2025 , Edited by admin on Mon Mar 31 21:27:32 GMT 2025

PRIMARY

INN

10262

Created by admin on Mon Mar 31 21:27:32 GMT 2025 , Edited by admin on Mon Mar 31 21:27:32 GMT 2025

PRIMARY

From	To
1_22	1_96
1_143	1_199
1_219	3_214
1_225	2_225
1_228	2_228
1_260	1_320
1_366	1_424
2_22	2_96
2_143	2_199
2_219	4_214
2_260	2_320
2_366	2_424
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					F3R7A4P04N

DEPATUXIZUMAB MAFODOTIN

CONJUGATE->CONJUGATE COMPONENT


					RO03J093CP

EPIDERMAL GROWTH FACTOR RECEPTOR

TARGET -> INHIBITOR

Interaction Type:

BINDING

Amount:


					IL87IM9EMV

ABT-806I

CONJUGATE->CONJUGATE COMPONENT

Related Record Type Details


					W984C353CG

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION			1_1; 2_1		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:CALCULATED	CHEMICAL
Molecular Formula	CHEMICAL