CARIPRAZINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H32Cl2N4O
Molecular Weight	427.411
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CARIPRAZINE

Structure Search

SMILES

CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)C3=C(Cl)C(Cl)=CC=C3)CC1

InChI

InChIKey=KPWSJANDNDDRMB-QAQDUYKDSA-N

InChI=1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17-

HIDE SMILES / InChI

Molecular Formula	C21H32Cl2N4O
Molecular Weight	427.411
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 00:42:14 UTC 2023` Edited by `admin` on `Sat Dec 16 00:42:14 UTC 2023`
Record UNII	F6RJL8B278
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CARIPRAZINE

Official Name

English

CARIPRAZINE [USAN]

Common Name

English

FRI-7000188

Common Name

English

cariprazine [INN]

Common Name

English

CARIPRAZINE [MI]

Common Name

English

GED-129

Code

English

3-(TRANS-4-(2-(4-(2,3-DICHLOROPHENYL)PIPERAZIN-1-YL)ETHYL)CYCLOHEXYL)-1,1-DIMETHYLUREA

Systematic Name

English

MP-214

Code

English

RGH-188

Code

English

Cariprazine [WHO-DD]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000175430

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

WHO-ATC

N05AX15

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

Code System Code Type Description

LACTMED

Cariprazine

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

PRIMARY

SMS_ID

100000128115

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

PRIMARY

MESH

C533287

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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PUBCHEM

11154555

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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EPA CompTox

DTXSID80232867

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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FDA UNII

F6RJL8B278

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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NCI_THESAURUS

C169826

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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CAS

839712-12-8

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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EVMPD

SUB34830

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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WIKIPEDIA

Cariprazine

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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DAILYMED

F6RJL8B278

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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IUPHAR

7671

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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MERCK INDEX

m11853

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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USAN

YY-06

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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INN

8920

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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RXCUI

1667655

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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RxNorm

HSDB

8310

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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ChEMBL

CHEMBL2028019

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

PRIMARY

CHEBI

90933

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

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DRUG BANK

DB06016

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

PRIMARY

DRUG CENTRAL

5037

Created by admin on Sat Dec 16 00:42:14 UTC 2023 , Edited by admin on Sat Dec 16 00:42:14 UTC 2023

PRIMARY

Related Record Type Details


					W4BO00H6K6

5-HYDROXYTRYPTAMINE RECEPTOR 2C

TARGET->WEAK INHIBITOR

Qualification:

Ki

Amount:


					19GBD6T9L7

D(2) DOPAMINE RECEPTOR

TARGET->PARTIAL AGONIST

Qualification:

Ki

Amount:


					G9XQ9S7T2F

D(3) DOPAMINE RECEPTOR

TARGET->PARTIAL AGONIST

Comments:

Most of the clinically used antipsychotics display fairly high affinity for D3 receptors in vitro, they lack significant D3 receptor binding in vivo. They also do not occupy D3 receptors in schizophrenic patients at clinically-relevant doses, despite having significant and expected D2 receptor occupancy. The lack of in vivo D3 receptor occupancy of currently used antipsychotics may be due to their inability to displace endogenous DA from these sites; especially since DA has approximately 20- fold higher affinity for D3 vs D2 receptors and D3 (but not D2) receptors exist predominantly in a high affinity state for DA”

Qualification:

Ki

Amount:


					NQI5D806LC

5-HYDROXYTRYPTAMINE RECEPTOR 2A

TARGET->WEAK INHIBITOR

Qualification:

Ki

Amount:


					KQD7C255YG

CARIPRAZINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					UKK18ES9TF

5-HYDROXYTRYPTAMINE RECEPTOR 1A

TARGET->PARTIAL AGONIST

Qualification:

Ki

Amount:


					6E2Z4UWILI

5-HYDROXYTRYPTAMINE RECEPTOR 2B

TARGET -> INHIBITOR

Qualification:

Ki

Amount:


					7H1P16DG5J

5-HYDROXYTRYPTAMINE RECEPTOR 4

TRANSPORTER -> NON-INHIBITOR

Qualification:

Ki

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:

Related Record Type Details


					286RCD7025

DESMETHYL CARIPRAZINE

METABOLITE ACTIVE -> PARENT

Comments:

minor enzyme involved in metabolism

Interaction Type:

MINOR

Qualification:

PLASMA


					6AY300X9G3

DIDESMETHYL CARIPRAZINE

METABOLITE ACTIVE -> PARENT

Comments:

activity same as CARIPRAZINE; steady state plasma level 400% of CARIPRAZINE

Interaction Type:

MAJOR

Qualification:

PLASMA


					6AY300X9G3

DIDESMETHYL CARIPRAZINE

METABOLITE ACTIVE -> PARENT

Interaction Type:

MINOR

Qualification:

PLASMA


					286RCD7025

DESMETHYL CARIPRAZINE

METABOLITE ACTIVE -> PARENT

Comments:

activity same as CARIPRAZINE, steady state level 30% of CARIPRAZINE

Interaction Type:

MAJOR

Qualification:

PLASMA

Related Record Type Details


					F6RJL8B278

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC