U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 16:47:21 GMT 2025
Edited
by admin
on Tue Apr 01 16:47:21 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
W4BO00H6K6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
5-HYDROXYTRYPTAMINE RECEPTOR 2C
Common Name English
5-HTR2C
Preferred Name English
5-HT1C
Common Name English
5-HT2C receptor
Common Name English
HTR1C
Common Name English
5HT2C
Common Name English
5HT-2C
Common Name English
5-HYDROXYTRYPTAMINE RECEPTOR 1C
Common Name English
SEROTONIN RECEPTOR 2C
Common Name English
5-HT2C
Common Name English
Code System Code Type Description
UNIPROT
P28335
Created by admin on Tue Apr 01 16:47:22 GMT 2025 , Edited by admin on Tue Apr 01 16:47:22 GMT 2025
PRIMARY
PHAROS
P28335
Created by admin on Tue Apr 01 16:47:22 GMT 2025 , Edited by admin on Tue Apr 01 16:47:22 GMT 2025
PRIMARY
FDA UNII
W4BO00H6K6
Created by admin on Tue Apr 01 16:47:22 GMT 2025 , Edited by admin on Tue Apr 01 16:47:22 GMT 2025
PRIMARY
From To
1_95 1_175
1_305 1_309
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_7
Related Record Type Details
Structure of 6-CHLORO-5-ETHOXY-N-(PYRIDIN-2-YL)INDOLINE-1-CARBOXAMIDE
INHIBITOR -> TARGET
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Ki
Structure of TEDATIOXETINE
INHIBITOR -> TARGET
Structure of DMBMPP
AGONIST -> TARGET
Structure of Dimethyltryptamine
AGONIST -> TARGET
Ki
Structure of Brilaroxazine
INHIBITOR -> TARGET
Structure of PALIPERIDONE
INHIBITOR -> TARGET
INHIBITOR
Ki
Structure of RS-102221
INHIBITOR -> TARGET
Binding Assay
IC50
Structure of SB-773812
INHIBITOR -> TARGET
Structure of Olanzapine
INHIBITOR -> TARGET
ANTAGONIST
Structure of LYSERGIDE
AGONIST -> TARGET
Ki
Structure of 1-[(1S,2S)-2-(5-Fluoro-2-propoxyphenyl)cyclopropyl]methanamine
AGONIST -> TARGET
Structure of DOTARIZINE
INHIBITOR -> TARGET
Structure of LORCASERIN
AGONIST -> TARGET
EC50
Structure of CPD-1
AGONIST -> TARGET
Structure of 5-MEO-AMT
AGONIST -> TARGET
Ki
Structure of BUFOTENINE
AGONIST -> TARGET
DOXEPIN
INHIBITOR -> TARGET
Structure of PF-04479745
AGONIST -> TARGET
Structure of WAY-163909
AGONIST -> TARGET
Emax, ~90%
EC50
Structure of SERTINDOLE
INHIBITOR -> TARGET
Structure of WAY-161503
AGONIST -> TARGET
Structure of MESCALINE
WEAK AGONIST->TARGET
Structure of 1B-LSD
PARTIAL AGONIST->TARGET
Ki
Structure of PIZOTYLINE
INHIBITOR -> TARGET
Structure of TCB-2
AGONIST -> TARGET
Structure of 2C-B-BUTTERFLY
AGONIST -> TARGET
Structure of DOET
PARTIAL AGONIST->TARGET
Structure of RISPERIDONE
INHIBITOR -> TARGET
INHIBITOR
Ki
Structure of ADATANSERIN
INHIBITOR -> TARGET
Structure of PIMAVANSERIN
INVERSE AGONIST->TARGET
AGONIST
Ki
Structure of MBL C-11
RADIOLIGAND->TARGET
Ki
Structure of Remlifanserin
INHIBITOR -> TARGET
IN-VITRO
Structure of ASP-2205
AGONIST -> TARGET
Structure of 1-METHYLPSILOCIN
AGONIST -> TARGET
Selective agonist for the 5-HT2C receptor (IC50 of 12 nM, vs 633 nM at 5-HT2A).
IC50
Structure of 5-MEO-NBPBRT
INHIBITOR -> TARGET
ANTAGONIST
Structure of A-372159
PARTIAL AGONIST->TARGET
Structure of CARIPRAZINE
WEAK INHIBITOR->TARGET
Ki
Structure of SDZ SER-082
INHIBITOR -> TARGET
Acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors, with good selectivity over other serotonin receptor subtypes and slight preference for 5-HT2C over 5-HT2B.
ANTAGONIST
Structure of ALD-52
PARTIAL AGONIST->TARGET
Structure of 1-PROPIONYL-LYSERGIC ACID DIETHYLAMIDE
PARTIAL AGONIST->TARGET
Structure of RITANSERIN
INHIBITOR -> TARGET
Ki
Structure of CYPROHEPTADINE
INHIBITOR -> TARGET
Structure of PHA-57378 Free Base
AGONIST -> TARGET
Structure of DERAMCICLANE
ANTAGONIST->TARGET
Structure of ORG-37684 Free Base
AGONIST -> TARGET
Structure of 6-FLUORO-DMT
AGONIST -> TARGET
Structure of PNU-22394
AGONIST -> TARGET
Structure of SB-200646
INHIBITOR -> TARGET
ANTAGONIST
Structure of Serotonin
AGONIST -> TARGET
AGONIST
Structure of AL-38022A
AGONIST -> TARGET
Structure of 25CN-NBOH
AGONIST -> TARGET
Assumed agonist
Ki
Structure of 2-BROMOMESCALINE
AGONIST -> TARGET
Structure of RO-60-0175
AGONIST -> TARGET
Structure of 2,5-Dimethoxy-4-trifluoromethylamphetamine
AGONIST -> TARGET
Structure of DEXFENFLURAMINE
ACTIVATOR -> TARGET
STIMULATES THE RELEASE OF SEROTONIN RESULTS IN APPETITE SUPPRESSION; LEAD TO 6-16 FOLD INCREASE IN SEROTONIN IN THE HYPOTHALMUS
Structure of VABICASERIN
AGONIST -> TARGET
EC50
Structure of FENFLURAMINE
AGONIST -> TARGET
STIMULATES THE RELEASE OF SEROTONIN RESULTS IN APPETITE SUPPRESSION; LEAD TO 6-16 FOLD INCREASE IN SEROTONIN IN THE HYPOTHALMUS
Structure of AGOMELATINE
INHIBITOR -> TARGET
Structure of M-CHLOROPHENYLPIPERAZINE
PARTIAL AGONIST->TARGET
Ki
Structure of PNU-181731
AGONIST -> TARGET
Structure of AL-37350A
AGONIST -> TARGET
Structure of CIMBI-36_5 C-11
RADIOLIGAND->TARGET
Structure of KETANSERIN
INHIBITOR -> TARGET
Binding Assay
IC50
Structure of 25CN-NBMD
WEAK AGONIST->TARGET
Ki
Structure of 4-HYDROXY-N-METHYL-N-ETHYLTRYPTAMINE
AGONIST -> TARGET
Structure of ORG-12962
AGONIST -> TARGET
Structure of ESMIRTAZAPINE
INHIBITOR -> TARGET
Structure of Bexicaserin
AGONIST -> TARGET
Structure of NORCLOZAPINE
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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