Datopotamab Deruxtecan

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 04:19:59 GMT 2025` Edited by `admin` on `Wed Apr 02 04:19:59 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	GD2OWY1DTK
Record Status	`Validated (UNII)`
Record Version

Download

Related Record	Type

Name

Type

Language

DATO-DXD

Preferred Name

English

Datopotamab Deruxtecan

Official Name

English

DS-1062

Code

English

datopotamab deruxtecan [INN]

Common Name

English

Immunoglobulin G1, anti-(human tumor-associated calcium signal transducer 2) (human-Mus musculus monoclonal MAAP-9001 ?1-chain), compd. with human-Mus musculus monoclonal MAAP-9001 ?-chain, dimer, thioether with N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens TACSTD2 (tumor-associated calcium signal transducer 2, membrane component chromosome 1 surface marker 1, M1S1, gastrointestinal tumor-associated antigen GA7331, pancreatic carcinoma marker protein GA733-1, epit

Common Name

English

ANTI-TROP2/DXD ANTIBODY-DRUG CONJUGATE DS-1062A

Common Name

English

DATOPOTAMAB DERUXTECAN [USAN]

Common Name

English

DS-1062A

Code

English

Datopotamab deruxtecan [WHO-DD]

Common Name

English

DS1062

Code

English

Code System Code Type Description

NCI_THESAURUS

C151967

Created by admin on Wed Apr 02 04:20:00 GMT 2025 , Edited by admin on Wed Apr 02 04:20:00 GMT 2025

PRIMARY

SMS_ID

300000020633

Created by admin on Wed Apr 02 04:20:00 GMT 2025 , Edited by admin on Wed Apr 02 04:20:00 GMT 2025

PRIMARY

CAS

2238831-60-0

Created by admin on Wed Apr 02 04:20:00 GMT 2025 , Edited by admin on Wed Apr 02 04:20:00 GMT 2025

PRIMARY

USAN

LM-52

Created by admin on Wed Apr 02 04:20:00 GMT 2025 , Edited by admin on Wed Apr 02 04:20:00 GMT 2025

PRIMARY

FDA UNII

GD2OWY1DTK

Created by admin on Wed Apr 02 04:20:00 GMT 2025 , Edited by admin on Wed Apr 02 04:20:00 GMT 2025

PRIMARY

INN

11218

Created by admin on Wed Apr 02 04:20:00 GMT 2025 , Edited by admin on Wed Apr 02 04:20:00 GMT 2025

PRIMARY

From	To
1_22	1_96
1_148	1_204
1_224	3_214
1_230	2_230
1_233	2_233
1_265	1_325
1_371	1_429
2_22	2_96
2_148	2_204
2_224	4_214
2_265	2_325
2_371	2_429
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_301
N	2_301

Related Record Type Details


					FUV56ZH0GB

DNA TOPOISOMERASE 1

TARGET -> INHIBITOR

Amount:


					BA3HQU7PO9

PARENT -> CONJUGATE

Amount:


					GM1W90Y88M

TUMOR-ASSOCIATED CALCIUM SIGNAL TRANSDUCER 2

TARGET->CONJUGATED TOXIN

Amount:

Datopotamab Deruxtecan-DLNK

SUB_CONCEPT->SUBSTANCE

Amount:

Related Record Type Details


					OQM5SD32BQ

N-[(1S,9S)-9-Ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3?,4?:6,7]indolizino[1,2-b]quinolin-1-yl]-2-hydroxyacetamide

METABOLITE ACTIVE -> PARENT

Amount:

Related Record Type Details


					GD2OWY1DTK

Datopotamab Deruxtecan

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_451] [2_451]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_224] [1_230] [1_233] [2_224] [2_230] [2_233] [3_214] [4_214]	SITE_SPECIFIC		Amount:	CYSTEINYL DERUXTECAN	I1NS1DHT5R

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL