U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 18:28:22 GMT 2025
Edited
by admin
on Tue Apr 01 18:28:22 GMT 2025
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
3T7136LE8K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALPHA-1A ADRENERGIC RECEPTOR
Common Name English
ADRA1C
Preferred Name English
Adrenergic ?1A receptor
Common Name English
ALPHA-1A ADRENOCEPTOR
Common Name English
Adrenergic ?1A
Common Name English
Adrenergic ?1A
Common Name English
ALPHA-1A ADRENORECEPTOR
Common Name English
Code System Code Type Description
FDA UNII
3T7136LE8K
Created by admin on Tue Apr 01 18:28:22 GMT 2025 , Edited by admin on Tue Apr 01 18:28:22 GMT 2025
PRIMARY
PHAROS
P35348
Created by admin on Tue Apr 01 18:28:22 GMT 2025 , Edited by admin on Tue Apr 01 18:28:22 GMT 2025
PRIMARY
UNIPROT
P35348
Created by admin on Tue Apr 01 18:28:22 GMT 2025 , Edited by admin on Tue Apr 01 18:28:22 GMT 2025
PRIMARY
WIKIPEDIA
ALPHA-1_ADRENERGIC_RECEPTOR
Created by admin on Tue Apr 01 18:28:22 GMT 2025 , Edited by admin on Tue Apr 01 18:28:22 GMT 2025
PRIMARY
From To
1_99 1_176
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_7
N 1_13
N 1_22
Related Record Type Details
AGONIST -> TARGET
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
Selectivity of silodosin determined in cloned human ?1-adrenergic receptor (?1-AR) subtypes in cultured Chinese hamster ovary cells.Silodosin has greater affinity for the ?1A-adrenergic receptor than for the ?1B-adrenergic receptor (by a factor of 583), minimizing the propensity for blood pressure-related adverse effects mediated by ?1B blockade.
Ki
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Highly selective ?1-adrenoceptor agonist that is approximately four times more potent than phenylephrine at constricting porcine IAS tissue in vitro.
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
BINDING
Kd
INHIBITOR -> TARGET
Ki
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
BINDING
IC50
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR
Ki
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
BINDING
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
BINDING
IC50
RADIOLIGAND->TARGET
REPRESENTIVE ALPHA-1 ADRENERGIC RECEPTOR
Ki

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_215] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL