U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 19:27:30 GMT 2025
Edited
by admin
on Tue Apr 01 19:27:30 GMT 2025
Protein Type RECEPTOR
Protein Sub Type TYROSINE KINASE
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
4796L35A70
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CD135
Preferred Name English
RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3
Common Name English
FLT3
Common Name English
FETAL LIVER KINASE-2
Common Name English
FMS-LIKE TYROSINE KINASE 3
Common Name English
FLK2
Common Name English
FL CYTOKINE RECEPTOR
Common Name English
FLT-3
Common Name English
STEM CELL TYROSINE KINASE 1
Common Name English
Code System Code Type Description
PHAROS
P36888
Created by admin on Tue Apr 01 19:27:30 GMT 2025 , Edited by admin on Tue Apr 01 19:27:30 GMT 2025
PRIMARY
FDA UNII
4796L35A70
Created by admin on Tue Apr 01 19:27:30 GMT 2025 , Edited by admin on Tue Apr 01 19:27:30 GMT 2025
PRIMARY
UNIPROT
P36888
Created by admin on Tue Apr 01 19:27:30 GMT 2025 , Edited by admin on Tue Apr 01 19:27:30 GMT 2025
PRIMARY
From To
1_9 1_39
1_77 1_88
1_173 1_180
1_206 1_215
1_246 1_304
1_342 1_381
1_355 1_366
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_17
N 1_74
N 1_125
N 1_280
N 1_297
N 1_325
N 1_328
N 1_447
N 1_476
N 1_515
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR->OFF-TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
ALSO ACTIVE AGAINST FLT3 ITD and FLT3 D835Y kinases were 1.8 nM and 1.0 nM
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
Kd
INHIBITOR -> TARGET
IC50
LIGAND->TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
ALSO ACTIVE AGAINST FLT3-ITD mutants
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
PRECLINICAL
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
COMPETITIVE INHIBITOR
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_546] [1_742] [1_767] TYROSINE O-PHOSPHATE 2R86C98KDX
AMINO ACID SUBSTITUTION [1_563] [1_565] [1_573] [1_700] [1_816] [1_929] [1_943] TYROSINE O-PHOSPHATE 2R86C98KDX
AMINO ACID SUBSTITUTION [1_548] [1_733] [1_967] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL