Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Tue Apr 01 19:27:30 GMT 2025
by
admin
on
Tue Apr 01 19:27:30 GMT 2025
|
| Protein Type | RECEPTOR |
| Protein Sub Type | TYROSINE KINASE |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
4796L35A70
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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P36888
Created by
admin on Tue Apr 01 19:27:30 GMT 2025 , Edited by admin on Tue Apr 01 19:27:30 GMT 2025
|
PRIMARY | |||
|
4796L35A70
Created by
admin on Tue Apr 01 19:27:30 GMT 2025 , Edited by admin on Tue Apr 01 19:27:30 GMT 2025
|
PRIMARY | |||
|
P36888
Created by
admin on Tue Apr 01 19:27:30 GMT 2025 , Edited by admin on Tue Apr 01 19:27:30 GMT 2025
|
PRIMARY |
| From | To |
|---|---|
| 1_9 | 1_39 |
| 1_77 | 1_88 |
| 1_173 | 1_180 |
| 1_206 | 1_215 |
| 1_246 | 1_304 |
| 1_342 | 1_381 |
| 1_355 | 1_366 |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_17 |
| N | 1_74 |
| N | 1_125 |
| N | 1_280 |
| N | 1_297 |
| N | 1_325 |
| N | 1_328 |
| N | 1_447 |
| N | 1_476 |
| N | 1_515 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET |
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INHIBITOR->OFF-TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
ALSO ACTIVE AGAINST FLT3 ITD and FLT3 D835Y kinases were 1.8 nM and 1.0 nM
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
Kd
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INHIBITOR -> TARGET |
IC50
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LIGAND->TARGET |
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
ALSO ACTIVE AGAINST FLT3-ITD mutants
IC50
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
PRECLINICAL
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
COMPETITIVE INHIBITOR
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
IC50
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Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| AMINO ACID SUBSTITUTION | [1_546] [1_742] [1_767] | TYROSINE O-PHOSPHATE | 2R86C98KDX | |||
| AMINO ACID SUBSTITUTION | [1_563] [1_565] [1_573] [1_700] [1_816] [1_929] [1_943] | TYROSINE O-PHOSPHATE | 2R86C98KDX | |||
| AMINO ACID SUBSTITUTION | [1_548] [1_733] [1_967] | DEXFOSFOSERINE | VI4F0K069V |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
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| Molecular Formula | CHEMICAL |
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