SORAFENIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H16ClF3N4O3
Molecular Weight	464.825
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of SORAFENIB

Structure Search

SMILES

CNC(=O)C1=CC(OC2=CC=C(NC(=O)NC3=CC(=C(Cl)C=C3)C(F)(F)F)C=C2)=CC=N1

InChI

InChIKey=MLDQJTXFUGDVEO-UHFFFAOYSA-N

InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)

HIDE SMILES / InChI

Molecular Formula	C21H16ClF3N4O3
Molecular Weight	464.825
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 04:53:43 UTC 2023` Edited by `admin` on `Sat Dec 16 04:53:43 UTC 2023`
Record UNII	9ZOQ3TZI87
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SORAFENIB

Official Name

English

SORAFENIB [USAN]

Common Name

English

SORAFENIB [MART.]

Common Name

English

SORAFENIB [EMA EPAR]

Common Name

English

2-PYRIDINECARBOXAMIDE, 4-(4-((((4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)AMINO)CARBONYL)AMINO)PHENOXY)-N-METHYL-

Systematic Name

English

BAY 43-9006

Code

English

SORAFENIB [MI]

Common Name

English

4-(4-(3-(4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)-N(SUP 2)-METHYLPYRIDINE-2-CARBOXAMIDE

Systematic Name

English

Sorafenib [WHO-DD]

Common Name

English

SORAFENIB [VANDF]

Common Name

English

BAY-43-9006

Code

English

sorafenib [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C129825

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

WHO-VATC

QL01XE05

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

NCI_THESAURUS

C1742

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

WHO-ATC

L01XE05

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

NDF-RT

N0000175076

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

FDA ORPHAN DRUG

675918

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

FDA ORPHAN DRUG

220206

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

FDA ORPHAN DRUG

185204

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

EMA ASSESSMENT REPORTS

NEXAVAR (AUTHORIZED: CARCINOMA, HEPATOCELLULAR, CARINOMA, RENAL CELL)

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

FDA ORPHAN DRUG

320310

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

LIVERTOX

NBK548944

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

FDA ORPHAN DRUG

229206

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

NDF-RT

N0000175605

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

NCI_THESAURUS

C1404

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

Code System Code Type Description

INN

8234

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

RXCUI

495881

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

RxNorm

LACTMED

Sorafenib

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

NCI_THESAURUS

C61948

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

MESH

C471405

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

PUBCHEM

216239

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

EPA CompTox

DTXSID7041128

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

USAN

UU-02

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

WIKIPEDIA

SORAFENIB

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

ChEMBL

CHEMBL1336

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

HSDB

8173

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

IUPHAR

5711

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

DRUG BANK

DB00398

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

DRUG CENTRAL

2459

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

FDA UNII

9ZOQ3TZI87

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

MERCK INDEX

m10116

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

Merck Index

CHEBI

50924

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

SMS_ID

100000091433

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

CAS

284461-73-0

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

EVMPD

SUB23139

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

DAILYMED

9ZOQ3TZI87

Created by admin on Sat Dec 16 04:53:43 UTC 2023 , Edited by admin on Sat Dec 16 04:53:43 UTC 2023

PRIMARY

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TRANSPORTER -> INHIBITOR


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MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 7

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VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3

TARGET -> INHIBITOR


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SORAFENIB TOSYLATE

SALT/SOLVATE -> PARENT


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VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2

TARGET -> INHIBITOR


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MITOGEN-ACTIVATED PROTEIN KINASE 11

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SERINE/THREONINE-PROTEIN KINASE B-RAF V600E

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RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3

TARGET -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					S54X4ZF5K5

SERINE/THREONINE-PROTEIN KINASE B-RAF

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					URP3G75J4S

MITOGEN-ACTIVATED PROTEIN KINASE 14

TARGET -> INHIBITOR


					5840721PJZ

OAT-2

TRANSPORTER -> SUBSTRATE

Amount:

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					O9ZAV58U4C

4-(4-((4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)CARBAMOYLAMINO)PHENOXY)PYRIDINE-2-CARBOXYLIC ACID

METABOLITE -> PARENT

Qualification:

FECAL


					5XYK65KIGD

METABOLITE ACTIVE -> PARENT

Interaction Type:

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Qualification:

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					N4T1W2J64C

METABOLITE -> PARENT

Qualification:

PLASMA


					S43YV45MJ6

METABOLITE -> PARENT


					83F1Z938Q0

METABOLITE -> PARENT

Qualification:

FECAL


					H2FQP001BP

METABOLITE -> PARENT

Qualification:

PLASMA

Related Record Type Details


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SORAFENIB RELATED COMPOUND 11

IMPURITY -> PARENT

Amount:

Related Record Type Details


					9ZOQ3TZI87

SORAFENIB

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC