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Details

Stereochemistry ACHIRAL
Molecular Formula C24H23FN4O3
Molecular Weight 434.4628
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Olaparib

SMILES

FC1=CC=C(CC2=NNC(=O)C3=CC=CC=C23)C=C1C(=O)N4CCN(CC4)C(=O)C5CC5

InChI

InChIKey=FDLYAMZZIXQODN-UHFFFAOYSA-N
InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)

HIDE SMILES / InChI
Molecular Formula C24H23FN4O3
Molecular Weight 434.4628
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
123738
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:37:57 UTC 2023
Edited
by admin
on Fri Dec 15 15:37:57 UTC 2023
Record UNII
WOH1JD9AR8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Olaparib
DASH   INN   MART.   MI   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
Olaparib [WHO-DD]
Common Name English
AZD2281
Code English
KEYLYNK-010 COMPONENT OLAPARIB
Code English
OLAPARIB [USAN]
Common Name English
OLAPARIB [ORANGE BOOK]
Common Name English
NSC-747856
Code English
OLAPARIB [JAN]
Common Name English
AZ2281
Code English
OLAPARIB [VANDF]
Common Name English
KU-0059436
Code English
olaparib [INN]
Common Name English
1(2H)-Phthalazinone, 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-
Systematic Name English
PIPERAZINE, 1-(CYCLOPROPYLCARBONYL)-4-(5-((3,4-DIHYDRO-4-OXO-1-PHTHALAZINYL)METHYL)-2-FLUOROBENZOYL)-
Systematic Name English
LYNPARZA
Brand Name English
4-[(3-{[4-(Cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorophenyl)methyl]phthalazin-1(2H)-one
Systematic Name English
AZD-2281
Code English
OLAPARIB [MI]
Common Name English
KU-59436
Code English
OLAPARIB COMPONENT OF KEYLYNK-010
Code English
OLAPARIB [MART.]
Common Name English
AZ-2281
Code English
Classification Tree Code System Code
NDF-RT N0000191623
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
EMA ASSESSMENT REPORTS LYNPARZA (AUTHORIZED: OVARIAN NEOPLASMS)
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
FDA ORPHAN DRUG 419013
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
FDA ORPHAN DRUG 417613
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
EU-Orphan Drug EU/3/07/501
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
FDA ORPHAN DRUG 409213
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
WHO-ATC L01XX46
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
FDA ORPHAN DRUG 655318
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
NCI_THESAURUS C62554
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
Code System Code Type Description
DAILYMED
WOH1JD9AR8
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
EVMPD
SUB32234
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
SMS_ID
100000124466
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
MERCK INDEX
m8185
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY Merck Index
ChEMBL
CHEMBL521686
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
DRUG CENTRAL
4907
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
NCI_THESAURUS
C71721
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
NSC
747856
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
INN
8685
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
RXCUI
1597582
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY RxNorm
IUPHAR
7519
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
FDA UNII
WOH1JD9AR8
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
CAS
763113-22-0
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
PUBCHEM
23725625
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
DRUG BANK
DB09074
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
MESH
C531550
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
CHEBI
83766
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
LACTMED
Olaparib
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
WIKIPEDIA
OLAPARIB
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
EPA CompTox
DTXSID60917988
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
NDF-RT
N0000191622
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY Poly(ADP-Ribose) Polymerase Inhibitors [MoA]
USAN
BC-28
Created by admin on Fri Dec 15 15:37:57 UTC 2023 , Edited by admin on Fri Dec 15 15:37:57 UTC 2023
PRIMARY
Related Record Type Details
Structure of Olaparib monohydrate
SOLVATE->ANHYDROUS
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
MAJOR
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> SUBSTRATE
Structure of Olaparib
EXCRETED UNCHANGED
FECAL
MATE-2
TRANSPORTER -> INHIBITOR
INHIBITOR
IC50
ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2
TRANSPORTER -> INHIBITOR
The clinical relevance of these findings is unknown.
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
Structure of Olaparib monohydrate
SALT/SOLVATE -> PARENT
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> INHIBITOR
INHIBITOR
IC50
OAT-3
TRANSPORTER -> INHIBITOR
INHIBITOR
IC50
POLY (ADP-RIBOSE) POLYMERASE 1
TARGET -> INHIBITOR
DT40 cells cytotoxicity
BINDING
IC50
OATP1B1
TRANSPORTER -> INHIBITOR
INHIBITOR
IC50
Structure of Olaparib
EXCRETED UNCHANGED
URINE
OCT-2
TRANSPORTER -> INHIBITOR
INHIBITOR
IC50
CYTOCHROME P450 3A4
METABOLIC ENZYME -> INHIBITOR
Inhibitor at higher concentrations than are clinically achieved.
MINOR
OCT-1
TRANSPORTER -> INHIBITOR
INHIBITOR
IC50
Structure of Olaparib hemi-2-propanol
SOLVATE->ANHYDROUS
MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1
TRANSPORTER -> INHIBITOR
INHIBITOR
IC50
Structure of Olaparib hemi-2-propanol
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of Olaparib
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Tmax PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC
NIH
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