IMIPRAMINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H24N2
Molecular Weight	280.4073
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of IMIPRAMINE

Structure Search

SMILES

CN(C)CCCN1C2=C(CCC3=C1C=CC=C3)C=CC=C2

InChI

InChIKey=BCGWQEUPMDMJNV-UHFFFAOYSA-N

InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C19H24N2
Molecular Weight	280.4073
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:15:13 UTC 2023` Edited by `admin` on `Fri Dec 15 15:15:13 UTC 2023`
Record UNII	OGG85SX4E4
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

IMIPRAMINE

Official Name

English

MELIPRAMINE

Common Name

English

IMIPRAMINE [HSDB]

Common Name

English

CLOMIPRAMINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Common Name

English

SERMONIL

Common Name

English

IMIPRAMINE [MI]

Common Name

English

imipramine [INN]

Common Name

English

IMIPRAMINE [VANDF]

Common Name

English

CRISTALIA

Common Name

English

TRIMIPRAMINE MALEATE IMPURITY D [EP IMPURITY]

Common Name

English

5-(3-(DIMETHYLAMINO)PROPYL)-10,11-DIHYDRO-5H-DIBENZ(B,F)AZEPINE

Systematic Name

English

N-(.GAMMA.-DIMETHYLAMINOPROPYL)IMINODIBENZYL

Common Name

English

BERKOMINE

Common Name

English

ORG-2463

Code

English

IMIPRAMINE [MART.]

Common Name

English

ANTIDEPRIN

Common Name

English

5H-DIBENZ(B,F)AZEPINE-5-PROPANAMINE, 10,11-DIHYDRO-N,N-DIMETHYL-

Systematic Name

English

NSC-169866

Code

English

TRIMIPRAMINE MALEATE IMPURITY, IMIPRAMINE- [USP IMPURITY]

Common Name

English

Imipramine [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QN06AA02

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

LIVERTOX

NBK547884

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

WHO-ATC

N06AA02

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

NCI_THESAURUS

C94727

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

NDF-RT

N0000175752

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

Code System Code Type Description

DRUG CENTRAL

1427

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

NCI_THESAURUS

C62039

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

INN

793

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

FDA UNII

OGG85SX4E4

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

MESH

D007099

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

EVMPD

SUB08152MIG

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

ECHA (EC/EINECS)

200-042-1

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

LACTMED

Imipramine

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

NSC

169866

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

EPA CompTox

DTXSID1043881

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

PUBCHEM

3696

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

ChEMBL

CHEMBL11

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

IUPHAR

357

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

DAILYMED

OGG85SX4E4

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

MERCK INDEX

m6232

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

Merck Index

RXCUI

5691

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

RxNorm

WIKIPEDIA

IMIPRAMINE

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

DRUG BANK

DB00458

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

CAS

50-49-7

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

SMS_ID

100000083920

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

CHEBI

47499

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

HSDB

3100

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

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Amount:


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IMIPRAMINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


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IMIPRAMINE PAMOATE

SALT/SOLVATE -> PARENT

Amount:


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CYTOCHROME P450 2D6

METABOLIC ENZYME -> SUBSTRATE

Comments:

Metabolizing reaction by CYP2D6: 2-Hydroxylation

Amount:


					2XX4SF4LD9

CYTOCHROME P450 2D15 (CANINE)

METABOLIC ENZYME -> SUBSTRATE

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METABOLIC ENZYME -> SUBSTRATE


					VK4SQL11C0

CYTOCHROME P450 1A2

METABOLIC ENZYME -> SUBSTRATE

Comments:

10%-20% OF TOTAL METABOLISM

Amount:


					31V857ZRPY

ALPHA-1-ACID GLYCOPROTEIN

BINDING PROTEIN->LIGAND

Amount:


					HN86OLH1NW

SODIUM-DEPENDENT NORADRENALINE TRANSPORTER

TARGET -> INHIBITOR

Amount:


					4007E25Z4Z

OCT-3

TRANSPORTER -> INHIBITOR


					CJZ26L1EGI

SODIUM-DEPENDENT SEROTONIN TRANSPORTER

TARGET -> INHIBITOR

Amount:


					HN86OLH1NW

SODIUM-DEPENDENT NORADRENALINE TRANSPORTER

TARGET -> INHIBITOR

Interaction Type:

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Qualification:

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Amount:


					CJZ26L1EGI

SODIUM-DEPENDENT SEROTONIN TRANSPORTER

TARGET -> INHIBITOR

Interaction Type:

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Qualification:

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Amount:


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MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1

TRANSPORTER -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Amount:


					482M00274D

OCT-2

TRANSPORTER -> INHIBITOR

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					TG537D343B

METABOLITE ACTIVE -> PARENT

Comments:

Imipramine has activities at both the serotonin and norepeinephrine transporters with greater affinity for the serotonin transporter while desipramine and 2-hydroxydesipramine have greater affinities for the norepinephrine transporter (Owens et al., 1997).

Amount:


					VO1Y07E90C

2-HYDROXYDESIPRAMINE

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CLOMIPRAMINE HYDROCHLORIDE

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Interaction Type:

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Qualification:

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Amount:


					1Y58DO4MY1

DESIPRAMINE HYDROCHLORIDE

PARENT -> IMPURITY

Interaction Type:

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Qualification:

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Amount:


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TRIMIPRAMINE MALEATE

PARENT -> IMPURITY

Amount:

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					OGG85SX4E4

ACTIVE MOIETY

Amount: